Nederlands Platform voor Farmaceutisch Onderzoek

Het Nederlands Platform voor Farmaceutisch Onderzoek (NPFO) presenteert onderzoek in de farmaceutische wetenschappen. De nadruk ligt op klinische toepassing zoals medicatieveiligheid, patiëntenzorg, formulering, analyse, farmacologie en casuïstiek.

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Alle artikelen
08 nov 2018

Begeleiding door artsen en apothekers tijdens antidepressivagebruik: behoeften van patiënten en suggesties ter verbetering

  • Rubriek:
    Korte bijdrage
  • Identificatie:
    2018;3:a1682
  • Auteur(s):
    M. Nederlof ab, D.C. Cath cd, L.J. Stoker a, A.C.G. Egberts ae en E.R. Heerdink aef*

Begeleiding door artsen en apothekers tijdens antidepressivagebruik: behoeften van patiënten en suggesties ter verbetering

Guidance by physicians and pharmacists during antidepressant therapy: patients’ needs and suggestions for improvement

OBJECTIVE

Guidance of patients treated with antidepressants is paramount for successful therapy. The aim was to assess patients’ needs and suggestions for improvement of guidance by physicians and pharmacists during second generation antidepressant (SGA) therapy.

DESIGN

Five focus group discussions were held with a total of 34 patients using an SGA.

METHODS

The discussions were conducted flexibly and responsively using a semistructured topic list. All focus group discussions were video-recorded and transcripts were analysed using ATLAS.ti for coding, thematic and open analysis.

RESULTS

Participants stated they were in need of better guidance. They suggested improving content of information during decisional moments, patient-health care professional communication and communication in-between health care professionals, and finally, organisation of guidance. Barriers to achieving improved guidance were cited.

CONCLUSION

Content, communication and organisation of guidance are pivotal for achieving optimal guidance. Participants mentioned that their current experienced guidance had limitations and brought up solutions for improvement. A next step would be to discuss the suggested solutions with health care professionals to assess their views and to discuss the possibility for implementation. After implementation, future studies could be aimed at determination of its impact on patients’ treatment efficacy, quality of life, treatment satisfaction and healthcare costs.

06 nov 2018

Fluoropyrimidines altijd op basis van DPYD-genotypering doseren

  • Rubriek:
    Referaat
  • Identificatie:
    2018;3:e1655
  • Auteur(s):
    Lonneke Timmers

Fluoropyrimidines altijd op basis van DPYD-genotypering doseren

02 nov 2018

De oudere migrant als klant in de openbare apotheek

  • Rubriek:
    Oorspronkelijk artikel
  • Identificatie:
    2018;3:a1681
  • Auteur(s):
    Bas Steunenberg *

De oudere migrant als klant in de openbare apotheek

The elderly migrant as customer at the pharmacy

BACKGROUND

Non-Western older immigrants experience poorer health outcomes than their Western counterparts, potentially due to limited access to health care services. A majority of the non-Western older immigrants has language problems and low health skills. As a consequence, they experience problems in their medication adherence and compliance.

OBJECTIVE

We tried to get more insight in how the older Moroccan-Dutch migrants and their next of kin at the pharmacy value their medication, how they adhere to medication and safe medication use.

DESIGN and METHODS

Semi-structured interviews were conducted with 20 older Moroccan-Dutch migrants (55 years or older, using five or more prescribed medicines) and 20 next of kin who support an older migrant for medication intake. Interviews were analysed using a qualitative research methodology. To reach the older migrants we deployed a so-called ethnic community health worker (CHW) at the pharmacy. She speaks the same language as the older migrants and has knowledge of the barriers they experience in medication adherence.

RESULTS

The older migrants could name the chronic disease for which they use medication. It seems hard for them to adhere to a medication intake regime due to daily hassles. When asking for more concrete knowledge about medication compliance skills, this topic seems to be a taboo and the older migrants fall silent. The older migrants and their next of kin agree that assistance for adherence to medication is necessary. The next of kin feel responsibility for this issue.

CONCLUSION

More attention to a firm relationship with the older migrants in the pharmacy is needed to talk about the problems they experience with medication adherence. Next to this, more attention should be paid to support their next of kin.

25 okt 2018

Identificeren van micro-organismen bij aseptische handelingen

  • Rubriek:
    Oorspronkelijk artikel
  • Identificatie:
    2018;3:a1680
  • Auteur(s):
    Frits A. Boom a*, Tjitske Veenbaas b, Mirjam Crul c, Milenko J.A.M.P. Pavičić d en Judith M. Ris a

Identificeren van micro-organismen bij aseptische handelingen

Identification of microorganisms in aseptic handling

OBJECTIVE

Determination of the relevance of identification of microorganisms found by microbiological Environmental Monitoring (isolates from EM) during aseptic handling.

METHODS

Identification of isolates from EM by microscopical examination, gram and spore staining and/or by MALDI-TOF. Isolates from EM in five hospital pharmacies were collected during one year and subdivided in 7 groups: Gram-positive and Gram-negative cocci, Gram-positive non-spore forming rods, Gram-positive spore forming rods, Gram-negative rods, fungi and yeast.

RESULTS

Gram-positive cocci were found in most cases (70-80 %), followed by Gram-positive rods (non-spore forming and spore forming; around 20%). Our results are comparable with the cleanroom microflora found in the pharmaceutical industry. The two cases described in this article, show that auditing gives more information about possible sources and causes of contamination than identification of micro-organisms.

CONCLUSION

The aim of identification is finding sources of contamination, resulting in corrective actions if EM results exceed the alert or action levels. We believe that the added value of identification, as a routine activity during aseptic handling is doubtful. However, knowing it is important to check if the cleanroom microflora is comparable to the expected microflora, we advise to do this once by using around 100 isolates from EM out of the LAF or biosafety cabinet and to repeat this every 3 years.

Identification is also valuable while building activities are taking place in the neighborhood of the cleanroom. Deviations from the expected cleanroom microflora will be indicative for inadequate preventive measures against contamination resulting from the building activities.

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